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Question 1
Types of muscle cells
skeletal, cardiac, smooth
Regulating body temperature
Storing fat
Producing red blood cells
Question 2
Which type of muscle tissue is responsible for
involuntary
movements?
Cardiac and smooth
Question 3
Which type of muscle tissue is responsible for
voluntary
movements?
Skeletal
Smooth
Visceral
Cardiac
Question 4
Type of muscle that connects skeleton to other structures
skeletal
Question 5
What type of muscle tissue are the walls of the heart made from?
Visceral
Cardiac
Smooth
Cardiac contract to pump blood
Question 6
What are the primary functions of smooth muscle tissue in the body?
contract walls, control blood flow and move contents of organs involuntary
pump blood
move skeleton
control blood flow and move contents of organs
Question 7
Types of joints
fibrous, synovial, cartilaginous
Question 8
What type of joints are generally immobile?
Fibrous joints
Cartilaginous joints
Sutures
Synovial joints
Question 9
WHat joints are freely movable
synovial joints
Question 10
What joints allow some movement?
cartilaginous
Question 11
How many bones are in the adult human skeletal system?
196
206
216
220
Question 12
Where do All the bones in the appendicular and most axial skeleton develop from?
mesoderm
Question 13
Which type of cells develop into the facial bones and rostral skull bones?
ectodermal cells
mesodermal cells
pluripotent stem cells
neural crest cells
Question 14
What process is responsible for the development of cartilage from the mesoderm layer?
chondrogenesis
neurogenesis
osteogenesis
ectogenesis
Question 15
What is the primary function of cartilage?
To form bones during embryonic development
To produce red blood cells
To regulate body temperature
Structurally support soft tissues and provide cushioned, low-friction surface within joints.
Question 16
What is chondrogenesis?
embryonic development of cartilage from the mesenchyme
From the mesoderm
From the ectoderm
From the endoderm
Question 17
What type of tissue is cartilage?
Muscle tissue
Tough, flexible connective tissue Avascular Lacks lymphatic vessels and nerves
Nervous tissue
Connective tissue
Question 18
Cartilage =
fibrin
glycogen
elastin
hyaluronic acid
Question 19
What does ECM include
collagen and proteoglycans that can bind a large amount of water
Question 20
Which cells in cartilage produce the ECM and maintain the cartilage long term?
osteoblasts
smooth muscle cells
fibroblasts
chondrocytes
Question 21
What process do chondroblasts undergo to contribute to the ECM?
apoptosis
cytokinesis
mitosis
meiosis
Question 22
What are the main types of cartilage
Elastic, hyaline, fibrocartilage
Question 23
What type of collagen is primarily found in elastic cartilage?
Type I Collagen
Type II Collagen
Type IV Collagen
Type III Collagen
Question 24
Which type of cartilage contains more chondrocytes?
Bone
Hyaline Cartilage
Elastic Cartilage
Fibrocartilage
Question 25
What type of collage is found in fibrocartilage?
Type III Collagen
Type IV Collagen
Type II Collagen
Type I Collagen
Question 26
What type of collage is found in hyaline cartilage?
type II
Question 27
Elastin cartilage characteristics
• least common • most elastic type • abundant network of elastic fibers • type II collagen
Question 28
What is the most common type of cartilage?
Cartilage with high collagen density
Hyaline cartilage
Fibrous cartilage
Elastic cartilage
Question 29
Where is hyaline cartilage commonly found?
In the brain
In flat bones
articular surfaces of movable joints, respiratory passages, and rib ends
In the digestive system
Question 30
What type of cartilage forms the temporary skeleton in the embryo?
Fibrous cartilage
Cartilage with high collagen density
Elastic cartilage
Hyaline cartilage, later gradually replaced by bone
Question 31
Hyaline cartilage density?
medium chondrocyte density
Question 32
What is osteoarthritis
gradual loss or changed physical properties of the hyaline cartilage that lines the joints
Question 33
What type of cartilage is characterized by the highest tensile strength but the least chondrocyte density?
Elastic cartilage
Hyaline cartilage
Fibrocartilage
Cartilage with highest chondrocyte density
Question 34
Where is fibrocartilage commonly found?
Ear cartilage
Rib cartilage
Nasal cartilage
Meniscus of knee, spinal intervertebral discs, tendon insertion (e.g. TMJ)
Question 35
What type of protein fiber is predominant in fibrocartilage?
Type I collagen, highest protein fiber density
Type III collagen
Type IV collagen
Type II collagen
Question 36
Fibrocartilage function
Provides tough and cushioning support for the bone
Question 37
What is bone classified as?
nerve tissue
supportive connective tissue with calcified extracellular matrix
cartilage
muscle tissue
Question 38
What type of matrix is found in bone?
Type II collagen matrix
Type III collagen matrix
Type I collagen matrix • provides network for hydroxyapatite crystals
Type IV collagen matrix
Question 39
How do bones contribute to the process of blood cell formation?
Bones enclose the bone marrow which is essential for blood cells formation.
Bones store blood cells
Bones transport blood cells
Bones produce blood cells directly
Question 40
Types of bones by shape
• long • short • flat • sesamoid • irregular (vertebra, facial)
Question 41
What type of bone is characterized by a long, cylindrical shape?
Flat bone
Irregular bone
Sesamoid bone
Long bone
Question 42
Which bone shape is typically associated with the skull?
Flat bone
Short bone
Long bone
Irregular bone
Question 43
What comprises the periosteum?
outer fibrous layer + inner cellular layer
Question 44
Function of the outer fibrous layer?
• protects bone • provides attachment for ligaments and tendons
Question 45
What does the inner cellular layer do?
• osteoblasts: secret bone matrix • chondroblast: produce cartilage
Question 46
Parts to a long bone
epiphysis metaphysis diaphysis (shaft)
Question 47
What is the name of the part of a long bone where growth occurs?
Metaphysis
Epiphyseal plate
Diaphysis
Epiphysis
Question 48
What is the term for the growth plate in bones?
Cortical Plate
Epiphyseal Plate
Diaphyseal Plate
Metaphyseal Plate
Question 49
What type of bone is closer to the surface and is denser?
Trabecular bone
Compact (cortical) bone
Spongy bone
Cancellous (trabecular) bone
Question 50
Which bone type has interconnecting cavities and is deeper?
Cancellous (trabecular) bone
Cortical bone
Spongy bone
Flat bone
Question 51
What are the two main components of bone structure?
Bone Matrix and Bone Cells
Bone Matrix and Bone Tissues
Bone Matrix and Bone Fibers
Bone Cells and Bone Proteins
Question 52
What is the primary component of the bone matrix?
Type II collagen framework infused with calcium crystals
Type I collagen framework infused with hydroxyapatite crystals Ca10(PO4)6(OH)2 + cells (osteocytes, osteoblasts and osteoclasts)
Type I collagen framework infused with calcium carbonate
Type III collagen framework infused with calcium phosphate
Question 53
Which cells are found within the bone structure?
osteocytes, osteoblasts, and osteoclasts
osteocytes, osteocytes, and osteocytes
osteocytes, osteoblasts, and osteocytes
osteocytes, osteoblasts, and osteoblasts
Question 54
Inorganic components of bone matrix?
Magnesium sulfate
Silicon dioxide
Sodium chloride
hydroxyapatite crystals - 60%
calcium + phosphate with small amount of bicarbonate, citrate, magnesium, potassium, and sodium ions
Question 55
Organic materials found in found in bone matrix?
Osteoid - 40%
• type I collagen, 90% • Ground substance
type V collagen
type II collagen
type III collagen
Question 56
What is ground substance?
proteoglycans and multi-adhesive glycoproteins like osteonectin
Question 57
What is osteonectin?
glycoprotein that: • is secreted by osteoblasts • has high affinity for calcium and collagen • is vital for bone mineralization
Question 58
Which protein is vital for bone mineralization?
Osteocalcin
Dentin matrix protein 1
Alkaline phosphatase
Osteopontin
Question 59
Osteoblast Osteoclast Osteocyte
OB: bone building OC: bone cutting OCy: bone cell
Question 60
Which cell type is responsible for forming the bone matrix?
Bone marrow cells
Osteogenic cells
Osteocytes
Osteoblasts
Question 61
Where do osteoblasts originate from?
meiosis
mitosis
from osteoprogenitor cells under the influence of growth factors (osteoblastogenesis)
lysosis
Question 62
What materials do osteoblasts produce?
osteoid protein + chondroitin sulphate (cartilage) + osteonectin
keratin
collagen
elastin
Question 63
Function of osteoblasts
promote growth and differentiation of osteoclasts
• via M-CSF • to maintain the balance between bone formation and resorption
Question 64
What happens to Older osteoblasts?
small population →
differentiate to osteocytes
some undergo apoptosis
Question 65
Where are osteocytes primarily found?
Cartilage
Muscle tissue
Blood vessels
cavities (lacunae) between bone matrix layers (lamellae) most abundant cells in bone
Question 66
What type of cells are osteocytes derived from?
myoblasts
chondrocytes
fibroblasts
neurons
Question 67
What network do osteocytes use to contact each other?
circulatory system
muscle fibers
network of canaliculi
nerve fibers
Question 68
What are osteoclasts?
Cells that produce new bone tissue
Epithelial cells lining the stomach
Small single-nucleated cells in bone marrow
essential for bone resorption and remodeling
• "bone cutting" • Large, multinucleated, motile cells • from bone marrow-derived monocytes (WBC)
Question 69
Osteoclast functions
1. bone turnover 2. involved in ion, nutrient and waste exchange 3. homeostasis: regulating calcium flow in/out of bone 4. express proteins that can regulate bone remodeling
Question 70
Which factors are required for osteoclast production?
Only M-CSF
RANK and OPG
RANKL and M-CSF
Only RANKL
Question 71
Define: RANK, RANKL, M-CSF
RANK = receptor activator of nuclear factor kappa RANKL = RANK ligand M-CSF = monocyte colony stimulating factor.
Question 72
What inhibits the differentiation of osteoclasts?
RANKL
Osteoprotegerin (OPG)
Calcium
Vitamin D
Question 73
How do osteoblast regulate osteoclast differentiation?
Monocytes
Tumor necrosis factor
Dentin matrix
Interleukin-6
Question 74
Which factor can promote osteoclastogenesis?
Interleukin-6 and tumor necrosis factor
Collagen
Osteocalcin
Vitamin D
Question 75
Which cells are the main source of RANKL in periodontitis?
Fibroblasts
Endothelial cells
Epithelial cells
B cells and T cells
Question 76
What is the decoy receptor for RANKL?
TRAF6
NF-kB
RANK
OPG
OPG inhibits formation of OC from OB RANKL needed for differentiation
Question 77
What molecules mediate RANK signaling?
JAK-STAT signaling
WNT signaling
TRAF6 and NF-κB
↑ actiavtes RANKL + RANK → OC
TGF-beta signaling
Question 78
Which does activated NF-kB induce?
NFATc4
NFATc2
NFATc3
activated T cells cytoplasmic 1 (NFATc1)
Question 79
What does NFATc1 do?
induces numerous osteoclast-specific target genes that are responsible for cell fusion and function
Question 80
What does osteoclast-mediated bone resorption release?
Increases bone density
Promotes muscle growth
TGF-β and IGF-1
• from bone matrix to induce
osteoblast
-mediated bone formation • secretes other mediators to promote/suppress OB differentiation
Enhances immune system function
Question 81
Which factors do OB secrete to promote OC development?
M-CSF, RANKL,
WNT5A
EGF, VEGF, FGF
IL-6, IL-8, TNF-α
GH, IGF-1, IGF-2
Question 82
Which factors do OB secrete to inhibit OC activity?
OPG
and WNT16
Question 83
What does the balance of RANKL and OPG indicate about bone health?
RANKL < OPG = homeostatic conditions RANKL > OPG = inflammatory conditions
It determines the rate of bone growth
It indicates the amount of calcium in the bones
It affects muscle strength and flexibility
Question 84
How often is spongy bone replaced?
Every 2 years
Every 3 to 4 years
Every 5 to 6 years
Every 7 to 8 years
Question 85
How often is compact bone replaced?
Every 8 years
Every 7 years
Every 12 years
Every 10 years
Question 86
What does the term 'osteogenesis' refer to?
cartilage formation
bone development
tendon development
muscle growth
Question 87
Which mechanism involves osteoblasts differentiating directly from osteoprogenitor cells?
Fibrous ossification
Intramembranous ossification • OB begin secreting osteoid • flat and irregular bones
Endochondral ossification
Membranous ossification
Question 88
In which type of ossification do osteoblasts invade a preexisting matrix of hyaline cartilage?
Endochondral ossification begin osteoid production after invasion
Fibrous ossification
Cartilaginous ossification
Intramembranous ossification
Question 89
What is the initial step in intramembranous ossification?
Calcification of the osteoid matrix
Mesenchymal cells cluster → develop into OBs → formation of a primary ossification center
Chondrocytes form a cartilage template
Osteoblasts deposit osteoid matrix
Question 90
second step of intramebranous ossification
OBs deposit osteoid matrix → matrix binds to calcium salts → becomes calcified
Fibroblasts
Chondrocytes
Myoblasts
Question 91
third step of intramembranous calcification
Continued matrix secretion + calcification → enlarges calcified areas + fuses w/ nearby ossification centers → formation of bone without cartilage backbone
Question 92
What is the initial structure that forms in the fetal stage of bone development?
Cancellous bone
Perichondrium
Hyaline cartilage
Periosteum
Question 93
Endochondral ossification - Fetal Stage
1. Fetal hyaline cartilage model 2. Cartilage calcifies → bone collar forms around diaphysis 3. Primary ossification center forms in diaphysis
Question 94
Endochondral ossification - Childhood Stage
4. Secondary ossification centers form in epiphyses 5. Bone replaces cartilage (except articular cartilage and epiphyseal plates)
Question 95
Endochondral ossification - Adult Stage
6. epiphyseal plate ossifies and forms epiphyseal lines
Question 96
What is the term for the thick plate of cartilage found in the growth region of a growing long bone?
Diaphyseal plate
Cortical plate
Epiphyseal plate
Metaphyseal plate
Question 97
In a mature long bone, what replaces the thick epiphyseal plate?
Growth plate
Endosteal line
Epiphyseal line
Cartilage plate
Question 98
What is the primary function of the epiphyseal plate?
Absorption of calcium
Regeneration of bone tissue
Longitudinal bone growth
Maintenance of bone density
Question 99
Zones of epiphyseal plate
1. Reserve Zone 2. Proliferative Zone 3. Zone of Maturation 4. Zone of Calcified Matrix
Question 100
Reserve Zone function
hyaline cartilage layer with chondrocytes
Question 101
Proliferative Zone function
• next layer toward the diaphysis • contains stacks of slightly larger chondrocyte that are rapidly dividing via mitosis
Question 102
Zone of Maturation and Hypertrophy function
• chondrocytes undergo final maturation • grow in size (hypertrophy) • chondrocytes secrete type X collagen • calcification of matrix begins → chondrocyte death
Question 103
What happens in Zone of calcified matrix?
Apoptosis
Mitosis
Calcification
Fibrosis
Question 104
What is appositional growth
growth in circumference through OBs
• form new bone tissue • OCs resorb old bone
Question 105
Where does bone resorption occur in appositional growth?
medullary cavity
compact bone
periosteum
growth plate
Question 106
What is the primary function of osteoclasts in bone remodeling?
Stimulating bone growth
Regulating blood calcium levels
Formation of new bone tissue
Osteoclasts erode and absorb previously formed bones.
Question 107
What is the sealing zone
edge of osteoclast are tightly sealed to the bone via integrins • create bone-resorbing compartmen
Question 108
What enzyme do osteoclasts secrete to break down the collagen matrix?
gelatinase
protease
lysozymal enzymes, mostly
collagenase
form Howship's lacunae (sho=allow depression)
elastase
Question 109
What pH level do osteoclasts create around the bone to dissolve hydroxyapatite?
around pH=6.0
around pH=5.0
around pH=7.4
~ 4.0 • secrete HCl to acidify the area • dissolves HA into soluble calcium and phosphate
Question 110
What molecule does osteoptegerin bind to?
Osteonectin
RANKL
slows foen activation of OCs
Osteocalcin
Osteopontin
Question 111
What protein does osteoblasts secrete to fill in lacunae?
Cartilage seam
Fibroblast seam
Collagen seam
Osteoid seam
Question 112
What substance is deposited on osteoid seam made from calcium and phosphate?
Hydroxyapatite
Phosphate seam
Calcium oxide
Calcium carbonate
Question 113
What do trapped OBs become?
Osteocytes
Question 114
Phases of bone repair
reactive reparative remodeling
Question 115
What happens during reactive phase of bone remodeling
Compact bone
1. clot formation 2. replaced by callus with regenerated blood vessels 3. inflammatory reaction 4. release of growth factors
Regenerating blood vessels
Fibrocartilaginous callus
Question 116
What happens during reparative phase?
Periosteum
Hard callus
1. CB + OB form 2. initial woven bone, named “callus” 3. hard callus from hyaline cartilage (type II collagen) 4. hyaline cartilage replaced by a lamellar bone (type I collagen)
Medullary cavity
Question 117
What is the final structure formed in the remodeling phase?
Compact bone at fracture site • takes weeks to months • includes bone resorption by OCs and redeposition by OBs
Medullary cavity
Primary bone
Fibrocartilaginous callus
Question 118
What is the initial tissue that replaces the hematoma in the reactive phase?
cartilage
fibrous connective tissue
bone marrow
muscle tissue
Question 119
What type of collagen is present in the final compact bone matrix?
type I collagen
type IV collagen
type III collagen
type II collagen
Question 120
What hormone is released by the parathyroid gland to regulate calcium levels?
Calcitriol
PTH (parathyroid hormone)
Glucagon
Thyroxine
Question 121
Which cells in bone tissue have receptors for PTH?
Osteoclasts
Osteoblasts
Myoblasts
Chondrocytes
Question 122
What effect does high PTH have on bone?
Synthetic effects
Anabolic effects
Resorptive effects
Neutral effects
Question 123
What effect does low PTH gave on the bone
Parathyroid hormone
Insulin
Calcitonin
anabolic effects
Question 124
Thyroid Gland and regulation of bone remodeling?
High calcium: stimulates calcitonin from thyroid → calcitonin binds to OCs → inhibit bone resorption → ↓ blood Ca levels
Question 125
How does estrogen affect bone resorption?
By increasing calcium absorption
By increasing bone-eroding cytokines
By stimulating bone growth
Inhibiting production of bone-eroding cytokines →
slows bone resorption
inhibits OB apoptosis, promotes OC apoptosis
Question 126
Lack and excess growth hormone during childhood?
Bone loss
Muscle atrophy
Dwarfism
Stunted growth
Question 127
What is the primary effect of mechanical stress on bone remodeling?
Stimulates muscle growth
Increases the rate of bone remodeling • bones that bear more weight, remodel at a higher rate (Wolff's Law)
Regulates blood pressure
Decreases bone density
Question 128
How does active vitamin D affect calcium levels?
Inhibits calcium absorption
Stimulates calcium absorption from the intestine → increases calcitonin level →
inhibit bone resorption
Has no effect on calcium absorption
Reduces calcium absorption
Question 129
What is the role of vitamin C in collagen production?
Inhibits collagen production
Stimulates bone resorption
Required for collagen production
Not involved in collagen production
Question 130
What does PTH primarily affect in hyperparathyroidism?
calcium levels (increase)
sodium levels
potassium levels
phosphate levels
Question 131
What is the relationship between calcium and phosphate levels in primary hyperparathyroidism?
both decrease
no change in phosphate
calcium decreases while phosphate increases
Calcium increases while phosphate decreases
Question 132
Where is alkaline phosphatase found and indicative of?
muscle cells
on OBs level is reflective of bone mineralization and formation
red blood cells
nerve cells
Question 133
Composition of enamel?
85%
90%
80%
92%
Question 134
Bone, dentin, and cementum composition?
8%
15%
70 % mineral, 20 % collagen and 10 % water
5%