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Question 1
What are the three anatomical regions of the pancreas?
Question 2
From which week does the pancreas begin developing?
Question 3
What is the origin of the pancreas and when does it start secreting insulin?
Question 4
What are the endocrine functions of the pancreas?
Question 5
What are the exocrine functions of the pancreas?
Question 6
What is the building block of the exocrine pancreas?
Question 7
What are acinar cells responsible for?
Question 8
What are ductal cells
Question 9
What are the zymogens secreted by acinar cells for protein digestion?
Question 10
What is the role of enterokinase in protein digestion?
Question 11
Acinar cell role in carbohydrate digestion
Question 12
Acinar cell role in lipid digestion
Question 13
Acinar role in nucleic acid digestions
Question 14
What is the role of bicarbonate in pancreatic ductal cell secretions?
Question 15
How do chloride and bicarbonate concentrations in ductal secretions vary with pancreatic flow rate?
Question 16
What are the three phases of pancreatic secretion regulation?
Question 17
What is the strongest stimulator for pancreatic secretions?
Question 18
What is the multiplicative effect in pancreatic secretion?
Question 19
What is the inhibitor of pancreatic secretion?
Question 20
What are the five different cell types in the endocrine pancreas and what hormones do they secrete?
Question 21
What is the precursor of glucagon?
Question 22
What enzyme is responsible for converting proglucagon into glucagon?
Question 23
What is the physiological role of glucagon?
Question 24
What are the stimuli that regulate glucagon secretion?
Question 25
What is the primary function of the alpha cell in the pancreas?
Question 26
Effects of glucagon on the brain
Question 27
Effects of glucagon on the pancreas
Question 28
Effects of glucagon on the liver
Question 29
Effects of glucagon on brown adipose tissue
Question 30
effects of glucagon on the heart
Question 31
What is the function of Somatostatin?
Question 32
Function of pancreatic polypeptide
Question 33
Functions of Ghrelin
Question 34
Function of amylin
Question 35
What is the structure of proinsulin?
Question 36
How is the endogenous insulin level determined?
Question 37
What is the role of SGLT-1 in glucose transport?
Question 38
What is the role of GLUT-2 in glucose transport?
Question 39
What is GLUT2 and what does it do?
Question 40
What is the effect of increased ATP/ADP ratio on insulin release?
Question 41
What are the factors that increase insulin secretion?
Question 42
What are the factors that decrease insulin secretion?
Question 43
What is the role of insulin in carbohydrate metabolism?
Question 44
What are the key steps in insulin signaling?
Question 45
Expression/Function of GLUT-1
Question 46
Expression/Function of GLUT-2
Question 47
Expression/Function of GLUT-3
Question 48
What is the primary function of GLUT-4?
Question 49
Where is GLUT-4 predominantly expressed?
Question 50
What is the primary mediator of insulin-stimulated glucose uptake?
Question 51
How does exercise affect insulin receptors?
Question 52
How does insulin effect carbohydrate metabolism?
Question 53
How does insulin effect lipid metabolism?
Question 54
Insulin effects on protein metabolism
Question 55
What is the common cause of acute pancreatitis in adults?
Question 56
What is the common cause of chronic pancreatitis in children?
Question 57
What is acute pancreatitis
Question 58
What is chronic pancreatitis
Question 59
Complications of Pancreatitis
Question 60
What percentage of the US population has diabetes?
Question 61
How many people have prediabetes in the US?
Question 62
What are the increased risks associated with diabetes?
Question 63
What is the goal of screening asymptomatic adults for prediabetes and type 2 diabetes?
Question 64
Diagnostic criterion for Diabetes Mellitus based on HbA1c?
Question 65
Diagnostic criterion for Diabetes Mellitus based on Fasting Plasma Glucose (FPG)?
Question 66
What is the definition of Glycated hemoglobin (A1C)?
Question 67
HbA1C Levels
Question 68
Fasting plasma glucose Levels
Question 69
Non-fasting or Random glucose test levels
Question 70
What is the Two-hour oral glucose tolerance test (OGTT)?
Question 71
What are the normal and diabetic ranges for the OGTT in mg/dL?
Question 72
What is the etiology of Type 1 Diabetes Mellitus?
Question 73
What percentage of diabetic patients have Type 1 Diabetes Mellitus?
Question 74
What are the two main factors contributing to the pathophysiology of Type 1 Diabetes Mellitus?
Question 75
What is the histological finding in the absence of insulin immunostaining?
Question 76
What is the onset age range for diabetes TI diagnosis?
Question 77
What percentage of insulin-secreting beta cells must be destroyed for diabetes symptoms to become obvious?
Question 78
Diabetes Type 1 Pathophysiology
Question 79
Clinical symptoms of T1D
Question 80
Rationale for polydipsia in T1DM
Question 81
Rationale for polyuria in T1DM?
Question 82
What is the key difference between Type 1 and Type 2 Diabetes Mellitus?
Question 83
What is the etiology of Type 2 Diabetes Mellitus?
Question 84
What is the prevalence of Type 2 Diabetes Mellitus?
Question 85
What is insulin resistance?
Question 86
How does the pancreas respond to insulin resistance?
Question 87
What is compensatory hyperinsulinemia?
Question 88
What happens to beta cell function in diabetic patients over time?
Question 89
What are the clinical manifestations of type 2 diabetes?
Question 90
What is acanthosis nigricans?
Question 91
What is the management strategy for Type 1 diabetes?
Question 92
What is the first-line management strategy for Type 2 diabetes?
Question 93
What is the blood glucose level that defines hypoglycemia?
Question 94
What are the symptoms of autonomic system activation associated with hypoglycemia?
Question 95
What are the neuroglycopenic symptoms associated with hypoglycemia?
Question 96
What is Diabetic Ketoacidosis (DKA)?
Question 97
What are the key pathophysiological steps in DKA?
Question 98
What are the symptoms of DKA (Diabetic Ketoacidosis)?
Question 99
What are the precipitating events for DKA?
Question 100
Management of DKA
Question 101
What is the definition of Diabetic Ketoacidosis?
Question 102
What is Ketosis and how does it differ from Diabetic Ketoacidosis?
Question 103
What is the pathophysiology of HHNKS?
Question 104
What are the precipitating events for HHNKS?
Question 105
What is the onset of the HHNKS?
Question 106
Symptoms of HHNKS
Question 107
What are the long-term complications of diabetes?
Question 108
What is neuropathy in the context of diabetes?
Question 109
What is the effect of hyperglycemia on the risk of infections?
Question 110
Hyperglycemia + Infection risks are attributed to
Question 111
What are the key factors contributing to xerostomia and hyposalivation in diabetes mellitus patients?
Question 112
Diabetes+ xerostomia complications
Question 113
What is the two-way relationship between diabetes and periodontal disease?
Question 114
What is Gestational Diabetes Mellitus (GDM)?
Question 115
What is the prevalence of GDM compared to Overt Diabetes?
Question 116
What is the pathophysiology of gestational diabetes?
Question 117
What are the complications of gestational diabetes?
Question 118
What is Diabetes Insipidus?
Question 119
What are the symptoms of Diabetes Insipidus?
Question 120
What are the two types of Diabetes Insipidus?